TY  - JOUR
T1  - HIgh-dose b vitamin supplements and alzheimer disease
AU  - Machanic BI
Y1  - 2009/03/11
N1  - 10.1001/jama.2009.212
JO  - JAMA
SP  - 1020
EP  - 1022
VL  - 301
IS  - 10
N2  - 
Prior studies have shown a relationship between low cerebrospinal fluid folate levels in patients with AD compared with normal controls. Low levels of L-methyl folate and methyl B12 have correlated with increased risk of cognitive impairment.2 It is possible that the patients in the study by Aisen et al were too advanced beyond a potential time window for benefit from B vitamin intervention to see a beneficial result.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2009.212
UR  - http://dx.doi.org/10.1001/jama.2009.212
ER  -