TY  - JOUR
T1  - SOdium bicarbonate vs sodium chloride in preventing contrast medium–induced nephropathy
AU  - Burgess W, Merten GJ, Rittase RA
Y1  - 2009/01/28
N1  - 10.1001/jama.2009.16
JO  - JAMA
SP  - 377
EP  - 380
VL  - 301
IS  - 4
N2  - 
To the Editor: In their randomized trial comparing sodium bicarbonate vs sodium chloride for prevention of contrast medium–induced nephropathy (CIN), Dr Brar and colleagues1 used a lower dose of bicarbonate than described in other studies2- 4 and found that this lower dose of bicarbonate was inadequate to significantly reduce CIN. Their study did not document urine pH as was done in other studies.2- 3,5 The bicarbonate concentration in their study was 130 mEq/L compared with 154 mEq/L in the other studies. The administered dose of bicarbonate anion was higher in the studies by Merten et al2 (by 18%), Ozcan et al3 (by 58%), and Recio-Mayoral et al4 (by 202%). The higher doses would likely result in a higher urine pH, although the bicarbonate effect on urine pH is nonlinear.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2009.16
UR  - http://dx.doi.org/10.1001/jama.2009.16
ER  -