TY  - JOUR
T1  - THe multiple risk factor intervention trial (mrfit)—importance then and now
AU  - Stamler J, Neaton JD
Y1  - 2008/09/17
N1  - 10.1001/jama.300.11.1343
JO  - JAMA
SP  - 1343
EP  - 1345
VL  - 300
IS  - 11
N2  - 
In 1986 in JAMA, we reported findings of the 6-year follow-up of the large cohort screened for the Multiple Risk Factor Intervention Trial (MRFIT).1 The article, challenging existing dogmas about the relationship between cholesterol and coronary heart disease (CHD), generated much interest. Now, the 25-year results are available with almost 7% (23 382) of the men deceased due to CHD.2- 4 The 1986 findings and conclusions regarding the relationship of a single measurement of serum cholesterol to premature CHD mortality are verified in depth by the 25-year data with extraordinary precision due to large size of the cohort, long follow-up, and a large number of CHD deaths.

SN  - 0098-7484
M3  - doi: 10.1001/jama.300.11.1343
UR  - http://dx.doi.org/10.1001/jama.300.11.1343
ER  -