TY  - JOUR
T1  - STandard-dose vs high-dose multivitamin supplements for hiv
AU  - Padayatty SJ, Levine M
Y1  - 2013/02/13
N1  - 10.1001/jama.2012.216991
JO  - JAMA
SP  - 545
EP  - 546
VL  - 309
IS  - 6
N2  - 
Higher doses of vitamins should result in higher plasma or tissue vitamin concentrations. For vitamin C, the dose-concentration relationship in healthy young women is sigmoidal.2 Rapid increases in plasma concentrations occur at intakes of 30 mg/d to 100 mg/d, with only small increases at higher intakes. For the doses of 80 mg/d (standard-dose regimen) and 500 mg/d (high-dose regimen) of vitamin C used in this study, predicted plasma vitamin C concentrations are 55 μM and 74 μM, respectively, using published dose-concentration curves.2

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.216991
UR  - http://dx.doi.org/10.1001/jama.2012.216991
ER  -