TY  - JOUR
T1  - NOninvasive approach to assess coronary artery stenoses and ischemia
AU  - Johnson NP, Kirkeeide RL, Gould K
Y1  - 2013/01/16
N1  - 10.1001/jama.2012.157189
JO  - JAMA
SP  - 233
EP  - 236
VL  - 309
IS  - 3
N2  - 
A large scatter between FFR and FFRCT most likely existed in the DeFACTO study,1 although it was not explicit in the article, leaving readers to infer its existence from the tables comparing dichotomized FFR and FFRCT. At best, the paired plot of FFR and FFRCT would mirror the results of the Diagnosis of Ischemia-Causing Stenoses Obtained Via Noninvasive Fractional Flow Reserve (DISCOVER-FLOW) trial,2 which showed wide limits of agreement between FFRCT and FFR of ±0.13 in addition to a slight bias of −0.02 (underestimation by FFRCT) and correlation of 0.72. The discordance may be even larger in the DeFACTO study because per-patient accuracy (73% vs 87%) and specificity (54% vs 82%) were lower than in the DISCOVER-FLOW study.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.157189
UR  - http://dx.doi.org/10.1001/jama.2012.157189
ER  -