TY  - JOUR
T1  - PAin panacea for opiophobia in infants?
AU  - Anand KS
Y1  - 2013/01/09
N1  - 10.1001/jama.2012.208359
JO  - JAMA
SP  - 183
EP  - 184
VL  - 309
IS  - 2
N2  - 
Intravenous acetaminophen (paracetamol) is suggested for use as an opioid-sparing analgesic for children requiring surgery1 or emergency care,2 despite limited data on its efficacy and toxicity in infants and children. In this issue of JAMA, the randomized trial by Ceelie and colleagues3 addresses this evidence gap by showing clinically significant reductions in morphine use among neonates or infants receiving postoperative analgesia. Among patients randomized to receive acetaminophen (n = 33) or morphine (n = 38) postoperatively, the cumulative morphine dose during the first 48 hours following surgery was 121 μg/kg (interquartile range, 99-264) vs 357 μg/kg (interquartile range, 220-605), respectively—a 66% relative reduction between groups (P < .001). There were no differences in the number of patients requiring morphine rescue doses or in pain scores.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.208359
UR  - http://dx.doi.org/10.1001/jama.2012.208359
ER  -