TY - JOUR T1 - WHy mole rats are cancer free AU - Hampton T Y1 - 2013/01/02 N1 - 10.1001/jama.2012.173449 JO - JAMA SP - 20 EP - 20 VL - 309 IS - 1 N2 - Researchers at the University of Rochester, in New York, and their colleagues found that fibroblast cells from the rats proliferate actively for 7 to 20 population doublings, after which the cells begin secreting interferon-beta, and the cultures undergo massive necrotic cell death within 3 days. This phenomenon depends on the p53 and retinoblastoma tumor suppressor proteins. SN - 0098-7484 M3 - doi: 10.1001/jama.2012.173449 UR - http://dx.doi.org/10.1001/jama.2012.173449 ER -