TY - JOUR T1 - ANesthesia and sleep circuits AU - Hampton T Y1 - 2012/12/12 N1 - 10.1001/jama.2012.77558 JO - JAMA SP - 2326 EP - 2326 VL - 308 IS - 22 N2 - Through staining experiments and electrophysiological studies, scientists from Children's Hospital of Philadelphia and the University of Pennsylvania found that the anesthetic drug isoflurane boosts activity in the ventrolateral preoptic nucleus (VLPO), a sleep-promoting brain area within the hypothalamus. Both natural sleep and anesthetic-induced unconsciousness produced similar increases in numbers of active neurons in this region. SN - 0098-7484 M3 - doi: 10.1001/jama.2012.77558 UR - http://dx.doi.org/10.1001/jama.2012.77558 ER -