TY - JOUR T1 - BIomedical research in an age of austerity AU - Moses III H, Dorsey E Y1 - 2012/12/12 N1 - 10.1001/jama.2012.14846 JO - JAMA SP - 2341 EP - 2342 VL - 308 IS - 22 N2 - The National Institutes of Health (NIH) budget would be reduced by $2.5 billion, or about 8.2%.1 Given that three-fourths of the NIH budget is committed to previously awarded grants, sequestration could affect predominantly new applications and young researchers. These budget reductions at the NIH and at other research agencies, such as $0.5 billion at the Centers for Disease Control and Prevention and $0.6 billion at the National Science Foundation (Table), will exacerbate tensions between large infrastructure projects (such as those that maintain public databases in genomics, clinical trials, and bioinformatics) and small investigator-initiated grants, which historically have been the primary source of new clinical insights. SN - 0098-7484 M3 - doi: 10.1001/jama.2012.14846 UR - http://dx.doi.org/10.1001/jama.2012.14846 ER -