TY  - JOUR
T1  - INterferon-γ-release assays for latent tuberculosis
AU  - Rosch EC
Y1  - 2012/11/21
N1  - 10.1001/jama.2012.12817
JO  - JAMA
SP  - 1971
EP  - 1971
VL  - 308
IS  - 19
N2  - 
As the population ages, many persons develop acute and chronic illnesses and may be exposed to immunomodulating therapies. In such situations, a negative PPD test may not ensure the absence of tuberculosis but merely reflect an acquired biological inability to respond to the protein antigen. The addition of anergy panel agents to the skin testing regimen increases the expense and complexity. Also, these agents are not routinely available in most primary care outpatient settings.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.12817
UR  - http://dx.doi.org/10.1001/jama.2012.12817
ER  -