TY  - JOUR
T1  - White matter hyperintensities in migraine: Reason for optimism
AU  - Friedman DI, Dodick DW
Y1  - 2012/11/14
N1  - 10.1001/jama.2012.36530
JO  - JAMA
SP  - 1920
EP  - 1921
VL  - 308
IS  - 18
N2  - 
An increasing body of evidence from cross-sectional population-based studies suggests that magnetic resonance imaging (MRI)–measured white matter hyperintensities in the brain are more common in people with migraine. In a meta-analysis of case-control studies, migraine was associated with an increased prevalence of white matter hyperintensities compared with absence of migraine (odds ratio [OR], 3.9; 95% CI, 2.26-6.72).1 A separate population-based study showed that the risk of supratentorial deep white matter hyperintensity was highest in women with migraine (OR, 2.1; 95% CI, 1.0-4.1), particularly among those with at least 1 migraine attack per month (OR, 2.6; 95% CI, 1.2-5.7).2 This study also demonstrated an increased prevalence of infratentorial (predominantly pontine) hyperintensities3 and posterior circulation territory infarctlike lesions in those with migraine and aura (OR, 13.7; 95% CI, 1.7-112), especially in those with at least 1 attack per month (OR, 15.8; 95% CI, 1.8-140).2 A third population-based study confirmed the association between migraine with aura and infarctlike lesions (OR, 12.4; 95% CI, 1.6-99.4, P for trend .005), but the lesions were not confined to the vascular territory of the posterior circulation.4

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.36530
UR  - http://dx.doi.org/10.1001/jama.2012.36530
ER  -