TY  - JOUR
T1  - INflammation and atherosclerosis
AU  - Hampton T
Y1  - 2012/11/07
N1  - 10.1001/jama.2012.14656
JO  - JAMA
SP  - 1729
EP  - 1729
VL  - 308
IS  - 17
N2  - 
In mice that did not express the low-density lipoprotein receptor and that were fed a high-fat, high-cholesterol diet, desmosterol (an intermediate in the cholesterol biosynthesis pathway) accumulated within these foam cells and suppressed the expression of genes that promote inflammation. Desmosterol was abundant in human atherosclerotic lesions obtained from the lower extremities of 3 patients.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.14656
UR  - http://dx.doi.org/10.1001/jama.2012.14656
ER  -