TY  - JOUR
T1  - TReatment of human immunodeficiency virus in adults
AU  - Yates TA, Sonnabend J
Y1  - 2012/10/17
N1  - 10.1001/jama.2012.12886
JO  - JAMA
SP  - 1522
EP  - 1523
VL  - 308
IS  - 15
N2  - 
To the Editor: While the Strategic Timing of Antiretroviral Treatment (START)1 and other trials are being conducted, decisions on the initiation of antiretroviral treatment at higher CD4 cell counts must rest on complex observational evidence. Without randomization, individuals who initiate treatment early may be systematically different from those who initiate treatment later. We are concerned that publication of the recent update to the International Antiviral (formerly AIDS) Society–USA (IAS-USA) Panel's recommendations2 may slow recruitment to ongoing randomized controlled trials by suggesting there is no longer equipoise.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.12886
UR  - http://dx.doi.org/10.1001/jama.2012.12886
ER  -