TY  - JOUR
T1  - CHildren’s deaths linked with postsurgical codeine
AU  - Voelker R
Y1  - 2012/09/12
N1  - 10.1001/2012.jama.11525
JO  - JAMA
SP  - 963
EP  - 963
VL  - 308
IS  - 10
N2  - 
The surgeries were performed to treat obstructive sleep apnea. FDA officials said it appeared that the 3 children who died, who were aged 2 to 5 years, were “ultrarapid metabolizers” who metabolize codeine much more quickly and completely than others. This trait results from a gene variant that makes the drug-metabolizing enzyme cytochrome P450 2D6 in the liver more active (http://www.fda.gov/Drugs/DrugSafety/ucm313631.htm). Overall prevalence of the inherited trait is 1% to 7% but reaches 29% in Ethiopian populations, the FDA reported. The agency has approved genetic tests that can detect the trait.

SN  - 0098-7484
M3  - doi: 10.1001/2012.jama.11525
UR  - http://dx.doi.org/10.1001/2012.jama.11525
ER  -