TY  - JOUR
T1  - CLinical trial data as a public good
AU  - Rodwin MA, Abramson JD
Y1  - 2012/09/05
N1  - 10.1001/jama.2012.9661
JO  - JAMA
SP  - 871
EP  - 872
VL  - 308
IS  - 9
N2  - 
Knowledge of the benefits and risks of prescription drugs is based mainly on published reports of clinical trials, yet the medical literature may present an incomplete and potentially biased sample of clinical trials.1 Trials with positive results generally are published more frequently than studies that conclude that a new drug poses greater risks or is no more effective than standard therapy or a placebo. Furthermore, some articles may distort trial findings by omitting important data or by modifying prespecified outcome measures. Lack of access to detailed information about clinical trials can undermine the integrity of medical knowledge.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.9661
UR  - http://dx.doi.org/10.1001/jama.2012.9661
ER  -