TY  - JOUR
T1  - Curbing the opioid epidemic in the united states: The risk evaluation and mitigation strategy (rems)
AU  - Nelson LS, Perrone J
Y1  - 2012/08/01
N1  - 10.1001/jama.2012.8165
JO  - JAMA
SP  - 457
EP  - 458
VL  - 308
IS  - 5
N2  - 
Prescription opioid analgesics have been used for decades for the outpatient treatment of acute medical, traumatic, and postoperative pain, as well as for chronic pain associated with malignancy and terminal disease. In the 1980s, a combination of factors, both patient-centered and business-oriented, led to the broader use of opioids for treatment of patients with chronic noncancer pain. This expanded use resulted in the dispensing of large quantities of opioids, of which a consequential, increasing minority was diverted to nonmedical uses, including inappropriate self-medication and recreational abuse.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.8165
UR  - http://dx.doi.org/10.1001/jama.2012.8165
ER  -