TY  - JOUR
T1  - PReventing hiv infections
AU  - Kuehn BM
Y1  - 2012/07/25
N1  - 10.1001/jama.2012.8754
JO  - JAMA
SP  - 331
EP  - 331
VL  - 308
IS  - 4
N2  - 
The researchers randomly assigned 1684 infants from 17 sites in the United States, Brazil, South Africa, and Argentina whose mothers had a peripartum diagnosis of HIV to receive either the usual zidovudine regimen for 6 weeks, this regimen plus 3 doses of nevirapine during the first 8 days of life, or the usual regimen plus nelfinavir and lamivudine for 2 weeks (Nielson-Saines K et al. N Engl J Med. 2012;366[25]:2368-2379). They found that the rate of transmission was 4.8% in the usual care group compared with 2.2% in the usual care plus nevirapine group and 2.4% in the 3-drug group. However, infants in the 3-drug group had elevated rates of neutropenia.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.8754
UR  - http://dx.doi.org/10.1001/jama.2012.8754
ER  -