TY  - JOUR
T1  - COx-2 inhibitors and heart risks
AU  - Hampton T
Y1  - 2012/06/06
N1  - 10.1001/jama.2012.5731
JO  - JAMA
SP  - 2247
EP  - 2247
VL  - 307
IS  - 21
N2  - 
A team led by researchers in Pennsylvania confirmed that COX-2 is expressed in cells lining blood vessels and revealed that selectively removing it from the mouse vasculature reduced urinary excretion of the major metabolite of prostacyclin. This predisposed mice to thrombosis and hypertension. Urinary excretion of the metabolite varied inversely with blood pressure across all mutant mice.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.5731
UR  - http://dx.doi.org/10.1001/jama.2012.5731
ER  -