TY  - JOUR
T1  - DRug linked with diabetes
AU  - Hampton T
Y1  - 2012/06/06
N1  - 10.1001/jama.2012.5729
JO  - JAMA
SP  - 2247
EP  - 2247
VL  - 307
IS  - 21
N2  - 
A transcription factor in muscle known as Yin Yang 1 (YY1) seems to play a key role. Rapamycin physically alters YY1 and causes it to bind to sequences that control the expression of certain genes, ultimately leading to decreased insulin signaling. Mice lacking YY1 did not develop diabetes when given rapamycin.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.5729
UR  - http://dx.doi.org/10.1001/jama.2012.5729
ER  -