TY  - JOUR
T1  - ARtemisinin-resistant malaria
AU  - Friedrich MJ
Y1  - 2012/05/16
N1  - 10.1001/jama.2012.5079
JO  - JAMA
SP  - 2017
EP  - 2017
VL  - 307
IS  - 19
N2  - 
Rising failure rates with artemisinin-combination treatments (ACTs) have been noted in malaria clinics along the northwestern border of Thailand. In a study involving 3202 patients from these clinics who had been given oral ACTs over a 10-year period (2001-2010), the researchers found increases in the time taken to clear P falciparum parasites from the bloodstream, known as the parasite clearance half-life. The proportion of slow-clearing infections—with a half-life equal to or more than 6.2 hours—also increased during this decade, from 0.6% to 20%. Genetic analysis showed that this decline in clearance rates resulted from genetic factors that conferred artemisinin resistance.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.5079
UR  - http://dx.doi.org/10.1001/jama.2012.5079
ER  -