TY  - JOUR
T1  - FEtal alcohol clues
AU  - Mitka M
Y1  - 2009/06/03
N1  - 10.1001/jama.2009.758
JO  - JAMA
SP  - 2202
EP  - 2202
VL  - 301
IS  - 21
N2  - 
Previously, scientists had discovered that exposing a frog embryo to alcohol during gastrulation reduces retinoic acid (RA) signaling (which is required for normal embryogenesis) and can result in the abnormalities associated with the disorder. Researchers theorized that alcohol exerts this effect on RA through the enzyme retinaldehyde dehydrogenase 2 (RALDH2), which appears in vertebrate embryos at the onset of gastrulation and is involved in metabolizing vitamin A to RA.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2009.758
UR  - http://dx.doi.org/10.1001/jama.2009.758
ER  -