TY  - JOUR
T1  - A new look at an old therapy
AU  - Califf RM
Y1  - 2012/05/09
N1  - 10.1001/jama.2012.4434
JO  - JAMA
SP  - 1972
EP  - 1973
VL  - 307
IS  - 18
N2  - 
Despite major advances in the care of patients with acute coronary syndrome over the past 3 decades, rates of early morbidity and mortality associated with this condition remain unacceptably high. In the 1980s, the concept of administering glucose, insulin, and potassium (GIK) to patients with suspected myocardial ischemia garnered substantial interest in both the research and practice communities. The therapy is remarkably simple and available globally at a low cost—an especially attractive feature given the increasing incidence of cardiovascular disease in low-income countries.1 The results of several clinical trials of moderate size seemed to suggest a bright future for GIK therapy2- 4; however, a subsequent large pragmatic trial found no benefit,5 and discussion of the treatment subsided.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.4434
UR  - http://dx.doi.org/10.1001/jama.2012.4434
ER  -