TY  - JOUR
T1  - EArly microbe exposure
AU  - Hampton T
Y1  - 2012/05/02
N1  - 10.1001/jama.2012.3995
JO  - JAMA
SP  - 1790
EP  - 1790
VL  - 307
IS  - 17
N2  - 
Using mouse models of irritable bowel disease and allergic asthma, a team led by scientists at Brigham and Women's Hospital and Harvard Medical School, in Boston, discovered that germ-free mice raised in sterile conditions had more invariant natural killer T (iNKT) cells accumulate in their colon and lungs, resulting in increased inflammation, compared with mice lacking only specific pathogens raised in nonsterile conditions (Olszak T et al. Science. doi:10.1126/science.1219328 [published online March 22, 2012]). Invariant NKT cells secrete proinflammatory molecules in response to foreign antigens and are thought to have a role in ulcerative colitis and asthma in humans.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2012.3995
UR  - http://dx.doi.org/10.1001/jama.2012.3995
ER  -