TY  - JOUR
T1  - SUpplementation in acute lung injury—reply
AU  - Rice TW, Wheeler AP, Thompson B
Y1  - 2012/01/11
N1  - 10.1001/jama.2011.1985
JO  - JAMA
SP  - 144
EP  - 146
VL  - 307
IS  - 2
N2  - 
In OMEGA, the supplement was provided as intermittent boluses to separate its effects from the overall quantity of enteral feeds. If the supplement had improved outcomes, the bolus design would have allowed treatment of patients unable to tolerate continuous or full enteral feedings, an important feature given that up to one-third of patients in previous trials were excluded for not tolerating the intervention. The design also allowed us to test for an interaction between OMEGA and EDEN. Although no interaction with EDEN was found (P = .47), early stopping of OMEGA limited us to detecting only a large interaction; we cannot exclude the possibility of a small interaction.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2011.1985
UR  - http://dx.doi.org/10.1001/jama.2011.1985
ER  -