TY  - JOUR
T1  - TIme-limited trials
AU  - Abernethy AP, Currow DC
Y1  - 2012/01/04
N1  - 10.1001/jama.2011.1954
JO  - JAMA
SP  - 33
EP  - 34
VL  - 307
IS  - 1
N2  - 
To the Editor: The Commentary on time-limited trials (TLTs) of treatment by Drs Quill and Holloway underscores the need for an explicit process to better manage “major interventions in circumstances in which the outcome is uncertain.”1 The basic tenets of the authors' proposal included measurement of end points; agreement on a time point for reevaluation of an individual's therapeutic response; and reconsideration of the intervention, with possible continuation, dose reduction, or cessation based on response.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2011.1954
UR  - http://dx.doi.org/10.1001/jama.2011.1954
ER  -