TY - JOUR T1 - MAking the call AU - Welch H Y1 - 2011/12/28 N1 - 10.1001/jama.2011.1898 JO - JAMA SP - 2649 EP - 2650 VL - 306 IS - 24 N2 - As you can probably tell, I am a fence-sitter (and, by the end of this essay, maybe even a flip-flopper). While I believe that media campaigns, advocacy groups, and physicians have systematically exaggerated the benefits of cancer screening and have downplayed—or, worse, ignored—its harms, I also believe that both benefits and harms exist. And no matter how well researchers can quantify this trade-off (and there is much room for improvement here), the metrics are different: small changes in cancer-specific mortality vs a boatload of hassle factors and fear, some unnecessary treatment, some resulting complications, and even a very few deaths (that can be missed in the measurement of cancer-specific mortality3). SN - 0098-7484 M3 - doi: 10.1001/jama.2011.1898 UR - http://dx.doi.org/10.1001/jama.2011.1898 ER -