TY  - JOUR
T1  - IMmunosuppression in sepsis
AU  - Ward PA
Y1  - 2011/12/21
N1  - 10.1001/jama.2011.1831
JO  - JAMA
SP  - 2618
EP  - 2619
VL  - 306
IS  - 23
N2  - 
Abundant evidence exists in both animals and humans with sepsis for the appearance of a “cytokine storm,” characterized by high plasma levels of proinflammatory cytokines and chemokines,1 clinical signs of fever, tachycardia, and tachypnea and followed rapidly by development of shock, multiorgan failure, and death.2 Additional evidence indicates that sepsis can be associated with a state of immunosuppression, broadly defined as lymphopenia and loss of immune function, though the timing, incidence, and nature of the immunosuppression remain poorly characterized, especially in humans.3

SN  - 0098-7484
M3  - doi: 10.1001/jama.2011.1831
UR  - http://dx.doi.org/10.1001/jama.2011.1831
ER  -