TY  - JOUR
T1  - DIet and diabetes link
AU  - Hampton T
Y1  - 2011/10/05
N1  - 10.1001/jama.2011.1391
JO  - JAMA
SP  - 1431
EP  - 1431
VL  - 306
IS  - 13
N2  - 
Investigators at the Center for Nanomedicine, a collaboration between the University of California, Santa Barbara, and Sanford-Burnham Medical Research Institute, found that the pancreatic beta cells of mice fed a high-fat diet had reduced expression of 2 transcription factors, FOXA2 and HNF1A. This in turn diminished expression of GnT-4a glycosyltransferase, an enzyme required for the transport of glucose across pancreatic beta-cell membranes. Affected mice exhibited signs typical of metabolic syndrome, including hyperglycemia, impaired glucose tolerance, and hyperinsulinemia. Preserving GnT-4a function in mice blocked the onset of diabetes, even in obese animals.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2011.1391
UR  - http://dx.doi.org/10.1001/jama.2011.1391
ER  -