TY  - JOUR
T1  - URinary sodium excretion and cardiovascular disease mortality
AU  - Cook NR
Y1  - 2011/09/14
N1  - 10.1001/jama.2011.1295
JO  - JAMA
SP  - 1083
EP  - 1087
VL  - 306
IS  - 10
N2  - 
First, the posited mechanism by which sodium affects CVD is through blood pressure. The authors, however, controlled for baseline blood pressure, thus removing the intermediate effect of sodium on CVD. A well-known principle of epidemiology is to avoid controlling for factors in the causal pathway. In their analysis of CVD outcomes, the authors included an additional analysis unadjusted for blood pressure, but this still controlled for antihypertensive medication. They inappropriately controlled for baseline blood pressure in analyses of incident hypertension, reversing the crude positive association.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2011.1295
UR  - http://dx.doi.org/10.1001/jama.2011.1295
ER  -