TY  - JOUR
T1  - IN vitro disease studies
AU  - Kuehn BM
Y1  - 2011/08/24
N1  - 10.1001/jama.2011.1197
JO  - JAMA
SP  - 815
EP  - 815
VL  - 306
IS  - 8
N2  - 
A major goal of the initiative is to find a noninvasive alternative to obtaining difficult-to-sample tissues such as heart and bone marrow. Being able to transform samples taken from accessible tissues such as blood or skin into iPSCs, and then differentiating them into cardiac, kidney, or other types of cells, could allow researchers an opportunity to study diseases in vitro. Such in vitro models would allow scientists to examine the effects of genetic alterations, treatments, and environmental influences on a disease process in the context of cells from a particular individual.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2011.1197
UR  - http://dx.doi.org/10.1001/jama.2011.1197
ER  -