TY  - JOUR
T1  - THe ethics of underpowered clinical trials
AU  - Janosky JE
Y1  - 2002/11/06
N1  - 10.1001/jama.288.17.2118
JO  - JAMA
SP  - 2118
EP  - 2119
VL  - 288
IS  - 17
N2  - 
I believe that the concept of statistical power as an absolute is misleading.
Statistical power is typically presented as a dichotomy that defines a cutoff
of .80 or greater. In fact, the concept of statistical power exists along
a continuum. A value for statistical power is intrinsically related to the
level of statistical significance, the level of treatment differences, variability
of response, research question of interest, and sample size. Separating statistical
power from these other parameters misinterprets the issue of statistical power.
A clinical trial has a certain level of statistical power associated with
it, given the level of these other parameters.

SN  - 0098-7484
M3  - doi: 10.1001/jama.288.17.2118
UR  - http://dx.doi.org/10.1001/jama.288.17.2118
ER  -