TY  - JOUR
T1  - GUidelines for treatment of anthrax
AU  - Tice AD
Y1  - 2002/10/16
N1  - 10.1001/jama.288.15.1845
JO  - JAMA
SP  - 1848
EP  - 1849
VL  - 288
IS  - 15
N2  - 
I was concerned, however, that the authors did not recommend loading
doses of antibiotics. Without a loading dose, serum levels do not reach a
steady state until after several doses of the drug have been administered.
For compartments such as infected lymph nodes and the mediastinum, effective
concentrations would be even more difficult to achieve. This may be a particular
problem for doxycycline, which has a half-life of 18 hours.2 A
loading dose of twice the standard intermittent dose should carry no more
likelihood of toxicity than a regular dose and may be appropriate for ciprofloxacin
as well.

SN  - 0098-7484
M3  - doi: 10.1001/jama.288.15.1845
UR  - http://dx.doi.org/10.1001/jama.288.15.1845
ER  -