TY  - JOUR
T1  - HEpatic γ-cystathionase deficiency in patients with aids
AU  - Martin J, Sastre J, de la Asunción J, Pallardó FV, Viña J
Y1  - 2001/03/21
N1  - 10.1001/jama.285.11.1444
JO  - JAMA
SP  - 1444
EP  - 1445
VL  - 285
IS  - 11
N2  - 
Most circulating GSH is synthesized in the liver where L-cysteine concentration is a rate-limiting factor. The liver obtains most of its cysteine from L-methionine through the trans-sulfuration pathway, which involves γ-cystathionase activity. Jahoor et al3 reported that the low GSH levels found in erythrocytes from HIV-infected subjects are due, at least in part, to a diminished availability of L-cysteine.3 However, the cause of this cysteine deficiency is not clear.

SN  - 0098-7484
M3  - doi: 10.1001/jama.285.11.1444
UR  - http://dx.doi.org/10.1001/jama.285.11.1444
ER  -