TY  - JOUR
T1  - CHolinergic markers in alzheimer disease—reply
AU  - Davis KL, Marin D, Purohit DP, et al
Y1  - 1999/12/15
N1  - 10-1001/pubs.JAMA-ISSN-0098-7484-282-23-jbk1215
JO  - JAMA
SP  - 2208
EP  - 2209
VL  - 282
IS  - 23
N2  - 
Bartus and Emerich also point to the plethora of experiments in animal
model systems (some of which have been contributed by our group), showing
that deficits in forebrain cholinergic systems can result in significant learning
and memory deficits. Although some studies have questioned the validity of
these findings,1- 2 we agree
that manipulations that adversely affect the forebrain cholinergic system
can impair learning, memory, and cognition. However, this fact cannot be interpreted
to mean that all cognitive deficits result from forebrain cholinergic system
dysfunction. It is quite possible that the dysfunction in early AD has its
origin in something other than the cholinergic system. The contention that
it is possible that cholinergic system deficits occur in AD "well in advance
of the death of cholinergic neurons" is a hypothesis that must be tested.
That such a state in animal model systems can produce cognitive deficits does
not obligate it to occur in AD, and the results of our studies, although not
definitive in this regard, cast doubt about this contention.

SN  - 0098-7484
M3  - doi: 10-1001/pubs.JAMA-ISSN-0098-7484-282-23-jbk1215
UR  - http://dx.doi.org/10-1001/pubs.JAMA-ISSN-0098-7484-282-23-jbk1215
ER  -