TY - JOUR T1 - MOderate- vs high-dose methadone for opioid dependence—reply AU - Strain EC, Bigelow GE, Liebson IA, Stitzer ML Y1 - 1999/12/08 N1 - 10-1001/pubs.JAMA-ISSN-0098-7484-282-22-jbk1208 JO - JAMA SP - 2121 EP - 2123 VL - 282 IS - 22 N2 - In Reply: Dr Grabowski and colleagues point out that their work has shown how the required frequency of clinic visits for methadone treatment can affect retention, while methadone dose influences rates of illicit opioid use.1 Methadone regulations require patients to attend clinics on a daily basis initially, and months or even years can elapse as patients gradually earn the right to attend on a less frequent basis. Their work suggests these attendance requirements may increase attrition from methadone treatment programs. This is an important point that needs to be considered as federal agencies work to revise current methadone regulations. It is also worth noting that some forms of insurance reimburse daily treatment delivered on-site but do not provide reimbursement for take-home doses of methadone. This can be another factor influencing the current practices of methadone clinics. SN - 0098-7484 M3 - doi: 10-1001/pubs.JAMA-ISSN-0098-7484-282-22-jbk1208 UR - http://dx.doi.org/10-1001/pubs.JAMA-ISSN-0098-7484-282-22-jbk1208 ER -