TY - JOUR T1 - LOw-dose hydrocortisone for chronic fatigue syndrome AU - Teitelbaum JE, Bird B, Weiss A, Gould L Y1 - 1999/05/26 N1 - 10-1001/pubs.JAMA-ISSN-0098-7484-281-20-jbk0526 JO - JAMA SP - 1887 EP - 1889 VL - 281 IS - 20 N2 - Our previously published pilot study2 and the work of Jefferies3- 4 suggests that using low-dose hydrocortisone (4 mg of hydrocortisone ≈ 1 mg of prednisone) in CFS at dosages of 7.5 to 20 mg/d is safe and effective. These low dosages have not caused the adrenal suppression3- 4 seen with the higher dosages (25-35 mg/d) used by McKenzie et al. They are also less likely to aggravate the already severe disruption of deep sleep present in CFS patients, as was seen in the study by McKenzie et al (P=.02 vs placebo). SN - 0098-7484 M3 - doi: 10-1001/pubs.JAMA-ISSN-0098-7484-281-20-jbk0526 UR - http://dx.doi.org/10-1001/pubs.JAMA-ISSN-0098-7484-281-20-jbk0526 ER -