TY  - JOUR
T1  - HIgh-altitude cerebral edema—reply
AU  - Hackett P, Yarnell P
Y1  - 1999/05/19
N1  - 10-1001/pubs.JAMA-ISSN-0098-7484-281-19-jbk0519
JO  - JAMA
SP  - 1794
EP  - 1794
VL  - 281
IS  - 19
N2  - 
The findings published by Dr Surks 33 years ago have been
confirmed in many subsequent studies. The mechanism of this shift of
fluid from the vascular space on ascent to high altitude and the exact
division of the fluid between the intracellular and interstitial spaces
are not as clear. Nor is it known whether the brain participates in
this fluid translocation to the same extent as other tissues. The
studies done by Surks et al were in persons without altitude illness.
In those who are ill with acute mountain sickness, a net fluid
retention or antidiuresis also takes place, which would aggravate any
fluid shift into the brain that might be taking place and contribute to
cerebral edema. However, the fluid shift from the vascular space does
not, in itself, provide a clue as to whether and to what extent the
brain is involved, and as to whether the brain edema is cytotoxic
(intracellular) or vasogenic (blood-brain barrier leak of proteins and
water).

SN  - 0098-7484
M3  - doi: 10-1001/pubs.JAMA-ISSN-0098-7484-281-19-jbk0519
UR  - http://dx.doi.org/10-1001/pubs.JAMA-ISSN-0098-7484-281-19-jbk0519
ER  -