TY  - JOUR
T1  - PLasma β-amyloid level, cognitive reserve, and cognitive decline
AU  - Okereke OI, Selkoe DJ, Grodstein F
Y1  - 2011/04/27
N1  - 10.1001/jama.2011.524
JO  - JAMA
SP  - 1655
EP  - 1656
VL  - 305
IS  - 16
N2  - 
To the Editor: Dr Yaffe and colleagues recently reported that lower levels of plasma β-amyloid 42/40 were related to worse rates of cognitive decline.1 A major finding was the observation of an interaction between cognitive reserve (as measured by education, literacy, or apolipoprotein E [APOE] ε4 status) and plasma β-amyloid 42/40. Although this finding is intriguing, and the consistency of the interaction across all 3 measures of cognitive reserve is suggestive, nonetheless caution is warranted. Yaffe et al1 found little association between β-amyloid 42/40 levels and cognitive decline in those with at least a high school education.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2011.524
UR  - http://dx.doi.org/10.1001/jama.2011.524
ER  -