TY  - JOUR
T1  - ABca1 gene mutations, hdl cholesterol levels, and risk of ischemic heart disease—reply
AU  - Tybjærg-Hansen A, Nordestgaard BG, Frikke-Schmidt R
Y1  - 2008/11/05
N1  - 10.1001/jama.2008.540
JO  - JAMA
SP  - 1997
EP  - 1998
VL  - 300
IS  - 17
N2  - 
In Reply:  The overall objective of our study was to examine whether a lifelong lowering of HDL cholesterol levels, without corresponding higher levels of plasma triglycerides or atherogenic remnant lipoproteins,1 was associated with increased risk of IHD. To test this hypothesis, we used heterozygotes for mutations in ABCA1 associated with low cellular cholesterol efflux, as well as with substantial, lifelong lowering of HDL levels, and showed no increase in risk. These results question the hypothesis of reverse cholesterol transport, an active research field. We agree with Dr Brunham and colleagues that genetic variants in ABCA1 may have effects on atherosclerosis independent of effects on HDL levels.2- 4 However, there are some inaccuracies in their letter.

SN  - 0098-7484
M3  - doi: 10.1001/jama.2008.540
UR  - http://dx.doi.org/10.1001/jama.2008.540
ER  -