RT Journal
A1 Perencevich EN, Lautenbach E
T1 INfection prevention and comparative effectiveness research
JF JAMA
JO JAMA
YR 2011
FD April 13
VO 305
IS 14
SP 1482
OP 1483
DO 10.1001/jama.2011.450
UL http://dx.doi.org/10.1001/jama.2011.450
AB 
Health care–acquired infections, particularly those due to antimicrobial-resistant bacteria, have received significant attention in recent years. Despite work focused on elucidating the epidemiology and effects of such infections, success in curbing their emergence remains elusive. Few new classes of antibiotics are even in the earliest stages of development, making efforts to prevent the emergence and spread of antimicrobial-resistant bacteria even more crucial. However, the evidence base on which potential infection-prevention strategies must be built is severely limited because very few of the necessary clinical trials have been conducted. The generation of such scientific evidence is constrained by the perceived difficulty of completing the necessary studies and limited federal funding available for assessing infection-prevention interventions.