RT Journal
A1 Kuehn BM
T1 STudy suggests gene may predict success of therapies for alcohol dependence
JF JAMA
JO JAMA
YR 2011
FD March 9
VO 305
IS 10
SP 984
OP 985
DO 10.1001/jama.2011.270
UL http://dx.doi.org/10.1001/jama.2011.270
AB 
A growing body of data links variation in the μ-opioid receptors with an individual's response to alcohol. The findings also show a connection between such variation and a patient's response to treatment with naltrexone, a drug that targets these receptors. Additionally, basic studies have demonstrated that variations in the genes that encode serotonin transporters affect the response to alcohol. Now a randomized controlled trial has demonstrated that the latter variants can predict the response of alcohol-dependent patients to treatment with ondansetron, a drug used to treat chemotherapy-associated nausea that targets the serotonin receptors.