RT Journal
A1 Rider LG, Miller FW
T1 DEciphering the clinical presentations, pathogenesis, and treatment of the idiopathic inflammatory myopathies
JF JAMA
JO JAMA
YR 2011
FD January 12
VO 305
IS 2
SP 183
OP 190
DO 10.1001/jama.2010.1977
UL http://dx.doi.org/10.1001/jama.2010.1977
AB The idiopathic inflammatory myopathies or myositis syndromes (the most common forms are polymyositis, dermatomyositis, and inclusion body myositis) are systemic autoimmune diseases defined by chronic muscle weakness and inflammation of unknown etiology and result in significant morbidity and mortality. Research suggests that categorizing heterogeneous myositis syndromes into mutually exclusive and stable phenotypes by using clinical and immune response features is useful for predicting clinical signs and symptoms, associated genetic and environmental risk factors, and responses to therapy and prognosis. Knowledge of myositis phenotypes should enhance clinicians' ability to recognize and manage these rare disorders.