RT Journal T1 UNsolved problems and future work in tuberculosis. JF Journal of the American Medical Association JO Journal of the American Medical Association YR 1899 FD August 26 VO XXXIII IS 9 SP 549 OP 550 DO 10.1001/jama.1899.02450610051005 UL http://dx.doi.org/10.1001/jama.1899.02450610051005 AB Great as is the progress of the last ten to fifteen years, in the study of tuberculosis, there yet remain many and weighty problems to be solved before we can hope for more decided results in our efforts at staying the ravages of this widespread disease. In a recent lecture1 Dr. E. L. Trudeau of Saranac Lake, N. Y., presents the aspect of some of these questions relating to tuberculosis in a manner which surely is helpful to all who are directly or even indirectly interested in this matter.He points out that more knowledge of the conditions which lead to variations in the manifestations of the disease is necessary. We are in the habit of explaining these differences as due to variations in virulence of the germ and in the resisting power of the tissues. But upon what factors does variation in virulence depend? And wherein lies predisposition,