RT Journal
T1 FAmily form of cystinuria.
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1899
FD August 5
VO XXXIII
IS 6
SP 362
OP 362
DO 10.1001/jama.1899.02450580056020
UL http://dx.doi.org/10.1001/jama.1899.02450580056020
AB The appearance of cystin in the urine has been attributed to disturbances in metabolism comparable with those that give rise to diabetes and gout. In support of this view, the appearance of the conditions in families and its hereditary transmission are cited as evidence. It has, however, been suggested that the condition arises in consequence of the activity of micro-organisms, as in some cases cadaverin and putrescin have been found in the urine in conjunction with cystin. Some recent observations by Cohn1 rather lend support to the former than the latter view. This observer reports the case of a girl, 7½ years old, who had been operated on several years previous for tuberculosis of the right knee-joint. For a year increased frequency of micturition had been noticed, and pain in the region of the bladder was complained of. These symptoms had increased in severity within three months, and the