RT Journal
T1 ACtive and passive immunity to anthrax.
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1899
FD May 6
VO XXXII
IS 18
SP 1005
OP 1005
DO 10.1001/jama.1899.02450450045012
UL http://dx.doi.org/10.1001/jama.1899.02450450045012
AB Having shown that sheep could be rendered immune to subcutaneous inoculation with virulent anthrax bacilli by previous treatment with blood-serum of infected animals, Sobernheim (Berliner Klin, Woch., March 27, p. 273) undertook to determine whether similar results could be obtained after spontaneous infection. The immunity conferred by treatment with the blood serum of immune animals or of those suffering from anthrax is both quickly acquired and quickly lost. Artificial protection would, therefore, be of use principally in the face of an epidemic. It was found, however, that this passive immunity could be combined advantageously with active immunity. With this object in view sheep were treated subcutaneously with a mixture of blood serum from infected animals and cultures of anthrax bacilli. The resulting infection was mild and the immunity considerable, the latter being still present a month and a half later. Further, the sheep were resistant not only to subcutaneous inoculation,