RT Journal T1 GOut, its pathology and treatment. JF Journal of the American Medical Association JO Journal of the American Medical Association YR 1899 FD April 29 VO XXXII IS 17 SP 954 OP 954 DO 10.1001/jama.1899.02450440052028 UL http://dx.doi.org/10.1001/jama.1899.02450440052028 AB The first part of this book is mainly a reproduction of the Goulstonian Lectures on "The Chemistry and Pathology of Gout," delivered in 1897. The second part discusses the causes, pathology, diagnosis and prognosis. The third is the important part of the book, in which the author gives the results of a large number of experiments made by himself to disprove many of the old theories believed in as to the cause of gout. Especially, he attempts to disprove the loss of alkalinity of the blood, as a cause, and shows that not only is the blood normal as to this condition, but that if it were not so it would not be conducive to the solubility of the sodium biurate. While he apparently shows by his experiments the untenableness of the older theories, he does not very satisfactorily give us anything in their stead. He discusses the effect of