RT Journal A1 Sajous CM T1 DR. harvey cushing's oration on the hypophysis cerebri JF Journal of the American Medical Association JO Journal of the American Medical Association YR 1909 FD August 21 VO LIII IS 8 SP 642 OP 642 DO 10.1001/jama.1909.02550080046011 UL http://dx.doi.org/10.1001/jama.1909.02550080046011 AB To the Editor:  —Those who expressed surprise when, over six years ago ("Internal Secretions," 1st Ed., 1903), I asserted that the anterior lobe of the pituitary played a leading rôle in the vital process per se, must now acknowledge the far-reaching meaning of Dr. Cushing's statement, in the Oration on Surgery, published in The Journal, July 24, that "more than one hundred total or partial hypophysectomies" had shown that "the anterior lobe of the hypophysis is a structure of such importance that a condition of apituitarism is incompatible with the long maintenance of life." While fully acknowledging the great value of Dr. Cushing's experiments, however, I must take exception to his conclusion that they sustain the theory that it is by means of a secretion capable of influencing the organism at large that the anterior pituitary carries on these all-important functions.That extracts of the posterior lobe raise the blood