RT Journal
T1 THe treatment of thyroidism by a specific cytotoxic serum
JF Journal of the American Medical Association
JO Journal of the American Medical Association
YR 1909
FD July 17
VO LIII
IS 3
SP 210
OP 210
DO 10.1001/jama.1909.02550030052005
UL http://dx.doi.org/10.1001/jama.1909.02550030052005
AB The fundamental premise of Rogers and Beebe1 in the treatment of thyroidism by an active antiserum is that the symptoms of the disease have their origin in a condition of hyperactivity of the thyroid. The serum is designed to neutralize, by its antitoxic property, the effects of the thyroid proteid in the circulation, and to inhibit by its cytotoxic property the secretory activity of the gland. It is prepared by the inoculation of animals with pure proteids from human thyroid glands. These authors find that if the pulp of an organ be injected into an alien species, antibodies to all the proteids so introduced are formed. Certain of these antibodies are specific for the organ used in producing them, while others are common to all the proteids of the species from which the organ is taken. By using nucleoproteid of organs that are as nearly blood-free as possible, instead