RT Journal A1 BURCH LE T1 APpendicostomy in pernicious anemia JF Journal of the American Medical Association JO Journal of the American Medical Association YR 1909 FD March 13 VO LII IS 11 SP 888 OP 889 DO 10.1001/jama.1909.25420370046004g UL http://dx.doi.org/10.1001/jama.1909.25420370046004g AB Pernicious anemia is a primary anemia, characterized by a progressive diminution in the number and changes in the form of the red blood corpuscles associated with a decrease in the amount of hemoglobin, which is not so marked as the reduction in red blood cells. The disease usually terminates fatally, whatever the method of treatment, but often there are periods of marked improvement, followed by relapse. It is not within the province of this paper to discuss the etiology, pathology or symptoms of this disease; I shall limit myself instead to the treatment in those cases that are supposedly due to anaerobic bacteria in the intestinal tract. Herter, who is the pioneer in this line of work, asserts that anaerobic bacteria in the intestinal tract play a prominent part in the etiology of pernicious anemia. He has shown that oxygen is found only in the small intestine, and that for