RT Journal T1 COngenital family cholemia JF Journal of the American Medical Association JO Journal of the American Medical Association YR 1909 FD March 6 VO LII IS 10 SP 776 OP 776 DO 10.1001/jama.1909.02540360032006 UL http://dx.doi.org/10.1001/jama.1909.02540360032006 AB One of the most fascinating features of the study of medicine is the constantly occurring changes. New signs are continually being described, and new diseases are constantly being split off from groups which appeared in the not distant past to be reduced to their final segregates. Among these relatively new conditions is one so far but little noted in this country, the disease known as congenital family cholemia or acholuric jaundice. Isolated instances and small groups of cases have been described for years, and recently Hawkins and Dudgeon1 have collected most of these, and have added some carefully studied cases of their own. It is probable that, like other apparently rare diseases, the condition will be found to be more common when more widely known.The main characteristics of this curious affection are indicated in its name; it tends to affect several members of a family, it is usually